Category Archives: In Depth

This is where I disassemble papers, critiquing and attempting objective analysis of the authors’ work. If you detect any bias or favoritism in this section, please inform me and/or tear me apart.

In Depth: Altered Neural Connectivity in Alzheimer’s

As I mentioned in my summary of the meat and potatoes of Perez-Cruz and friends’ paper, this group largely reproduced previous findings, but they also added a new dimension of depth to those findings. Another attractive aspect of the paper … Continue reading

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In Depth: Neurons that Change Shape! Implications for Treatment of Depression?

After reading about the meat and potatoes of Chen and friends’ paper, you may or may not agree that Layer 2/3 “dynamic zone” interneurons seem to control ocular dominance plasticity. Below, I have dissected the paper in more depth to … Continue reading

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In Depth: A Weird Synapse In Our Ears Gets Weirder

As I said in my description of the meat and potatoes of Nouvian and friends’ paper, they showed that the inner hair cell’s (IHC) ribbon synapses don’t play by rules. In truth it was established quite early on that these synapses … Continue reading

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In Depth: Untangling Starburst Amacrine Cells

In a bet to unravel one of the longest standing controversies in visual neuroscience, and thus in neuroscience period, Briggman and friends have pioneered a new combination of calcium imaging and electron microscopy. This is the arguably the more impressive sibling of … Continue reading

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In Depth: Functional Connectomics of the Primary Visual Cortex

Bock and friends have produced a formidable paper, pioneering the new combo of functional calcium imaging and serial recostruction electron microscopy, a technique that will undoubtedly revolutionize the way we study neural circuitry. Numerous sources have called their work (and … Continue reading

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In Depth: A Map of 16,000 Fruit Fly Neurons

Hopefully as you see in a bit more depth how the paper unfolds, it will become more apparent that Chiang and friends make few real findings or even predictions. However, aside from the transparency and respect for freedom of knowledge … Continue reading

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In Depth: Using Rabies Virus to Study Neural Circuits

Two papers lead up to the most recent publication by Weible and friends. The first (by Wikersham and friends) introduces a modified rabies virus that is only capable of initial infection and reproducing, but can’t move transsynptically from the initially … Continue reading

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